Traditional understanding posited that excess sebum clogs pores, fostering the proliferation of Cutibacterium acnes bacteria, which in turn triggers inflammation.
However, new research paints a more complex picture. Comprehensive studies by Professor Harald Gollnick and Dr. James J. Leyden of the Global Alliance to Improve Outcomes in Acne have systematically explored the role of inflammation in acne, revealing that inflammation is not merely a participant but a driving force in acne development.
Inflammation: The Key Player in Acne Development
“Dysbiosis and sebum changes provoke early inflammation, leading to clogged pores and bacterial proliferation, which culminates in more inflammation.” This new insight places inflammation at the heart of acne formation, highlighting that inflammation is not just a reaction but a critical factor throughout the acne lifecycle.
- Skin Microbiome Imbalance and Its Inflammatory Chain Reaction
An imbalance in the skin’s microbiome—known as dysbiosis—can trigger inflammatory processes, setting the stage for acne development.
- Sebum: The Oily Instigator of Inflammation
Sebum, the skin’s natural oil, is crucial for protection and hydration. However, when produced in excess or altered in composition, it can lead to adverse outcomes. Researchers have uncovered the link between sebum changes and inflammation, explaining how these changes can initiate a chain reaction culminating in acne.
Key Ingredients with Proven Anti-Inflammatory Effects
These ingredients are backed by medical research and clinical trials for their effectiveness in combating inflammation and treating acne:
- Tea Tree Oil
Controls Oils: Helps regulate sebum production, reducing oiliness and preventing clogged pores.
Anti-Inflammatory: The main component, terpinen-4-ol, has strong antibacterial properties that inhibit the growth of Cutibacterium acnes and reduce inflammation.
- Salicylic Acid
Targets Pimples: As a beta-hydroxy acid (BHA), it penetrates pores to dissolve dead skin cells and excess oil, preventing and treating acne.
Anti-Inflammatory: Inhibits the production of inflammatory mediators, reducing redness and swelling.
- Centella Asiatica
Soothes Redness: Contains active compounds such as asiaticoside and asiatic acid, which soothe the redness.
Anti-Inflammatory: Centella Asiatica can suppress the release of inflammatory mediators like cytokines, reducing skin inflammation.
